Professor Dr. PhD Snezana Smickoska (Chief of the Departement)

» Medicine and Health     

» Radiation therapy, oncology, breast cancer

Radiotherapy and chemotherapy

Involved in clinical international trials considering radiotherapy, chemotherapy and targeted therapy of malignant diseases

1. Phase II study evaluating efficacy and safety of doxorubicin plus Taxol (paclitaxel) combination as first line treatment for patients with metastatic breast cancer
(Prospective, phase II single center study-2000)

2. The International Adjuvant Lung Cancer Trial Collaborative Group. CISPLATIN-BASED ADJUVANT CHEMOTHERAPY IN PATIENTS WITH COMPLETELY RESECTED NON-SMALL-CELL LUNG CANCER. The New England Journal of Medicine, Vol.350, No.4, 351-360, 2004
(A large scale trial evaluating adjuvant chemotherapy after curative resection of non-small cell lung cancer-June 1995)

3. A Phase III study of DPPE (Tesmilifene) combine with Epirubicin and Cyclophosphamide versus Epirubicin and Cyclophosphamide alone as first line Treatment in Metastatic/Recurrent Breast Cancer Pharm-Olam YMB 1002 - 02 Study (2005, on-going)

4. An expanded program of TarcevaTM (erlotinib, OSI-774) in treatment of patients with advanced stage IIIB/IV non-small-cell lung cancer
(An open-label, non-randomized, multicentre expanded access clinical trial of Tarceva as single agent, 2005, on-going)

5. Daily oral perifosine (ZEN-004) in combination with radiotherapy in non-small cell lung cancer patients (june 2007-on-going)

6. Project MAK /6/010 “Upgrading of radiotherapy Facilities and Introducing a New Radiotherapy Techniques in the FYR Macedonia” 2007-2009, IAEA

7. An international multi-centre open-label 2-arm phase III trial of adjuvant bevacizumab in triple negative breast cancer (2008- on-going)

8. A non comparative, multicenter, repeat dose safety in use study of neukine (filgrastim) in patients receiving chemotherapy known to induce neutropenia. Protocol code: kwi 300 105 (2008- on-going)

2008-12-12 / 2010-04-14