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Faculty of pharmacy
Faculty of pharmacy
Pharmacognosy nad Phytochemistry

 Contact data
StreetVodnjanska 17 
ZIP, City, State 1000 - Skopje (FYR of Macedonia) 
 Contact person

Msci.pharm Gjoshe Stefkov (teaching assistent)
 Activities in Research and Development

 RTD sectors:
» Bio technology     
» Diagnostics     
» Pharmaceutics     
» Agriculture     

 Area of expertise (keywords)
» Pharmacognosy
» phytochemistry
» medicinal and aromatic plants
» diabetes
» antidiabetic
» Teucrium
» antiinflamatory
» laboratory animal models
» analitics of medicinal plants
» flavonoids
» essential oil
» pesticides
 RTD Experiences

 Description of RTD activities
MSci thesis: complay results from diferent investigations of the representatives of the genus Teucrium (T. polium; T.montanum; T. scordium; T. chamaedrys) in Macedonia that includes :
• Horological and ethnofarmagological investigations
• Phytochemical investigation of the flavonoids:
o Extractions and HPLC;GC-MS qualitative and quantitative analysis;
o Separation, isolation (semipreparative HPLC), structural characterisation and identification (NMR; GC-MS) of unknown flavonoid compound;
o Distribution and localisation of the flavonoids in the plants
o Season variability of flavonoid compounds
• Chemotaxonomical analysis
• Bioactivity of dry extracts from T. polium
o Pharmacological investigations-in vivo experimental design for assesment of:
 hypoglycemic effects,
 antihiperglycemic effects,
 hypolipidemic effects
• evaulated in normal and streptozotocin-hyperglycemic rats,
• single and multiple dose,
• acute and subchronic treatment
• intraperitoneal and intragastral administration,
• comparation with Glibenclamide (widely used oral antidiabetic)
o Toxicological investigations:
 biochemical assesment of AST, ALP, ALT, LDH, CPK, Urea, Creatinin, Total proteins, Albumins, Na, K as bioindicators of the funcion of the kidneys, hart, and hepar
 histomorphological assesment of kidneys, hart, lungs and hepar

 Experiences in international Programmes
Chair of Working group for Medicinal and aromatic plants-SEEDnet project
National coordinator for Medicinal and aromatic plants in ECPGR

 Inserted / Updated
2007-09-07 / 2007-09-07